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Published Date: 2025-11-19 | Pages: 77 | Tables: 77 | Medical Care
The global market for PNH and aHUS was estimated to be worth US$ 5826 million in 2024 and is forecast to a readjusted size of US$ 8940 million by 2031 with a CAGR of 6.4% during the forecast period 2025-2031.
PNH and aHUS, both are extremely rare and genetic diseases. Due to PNH, destruction of red blood cells of a person occurs quite sooner than it should. It is an acquired hematopoietic stem cell disorder. Hematopoietic stem cells are developed in bone marrow and eventually turn into red blood cells, white blood cells and platelets. A person with PNH has some defected hematopoietic cells which create defective red blood cells. These defective cells are highly susceptible to premature destruction by the complement system. aHUS is a disorders in which blood clots are formed in small blood vessels throughout the body. TMA can lead to heart stroke, attack, kidney failure and death.
United States is the largest consumption place, with a consumption market share nearly 52.1% in 2019. Following United States, Europe is the second largest consumption place with the consumption market share of 26.2%.
This report aims to provide a comprehensive presentation of the global market for PNH and aHUS, focusing on the total sales revenue, key companies market share and ranking, together with an analysis of PNH and aHUS by region & country, by Type, and by Application.
The PNH and aHUS market size, estimations, and forecasts are provided in terms of sales revenue ($ millions), considering 2024 as the base year, with history and forecast data for the period from 2020 to 2031. With both quantitative and qualitative analysis, to help readers develop business/growth strategies, assess the market competitive situation, analyze their position in the current marketplace, and make informed business decisions regarding PNH and aHUS.
Market Segmentation
By Company
Alexion Pharmaceuticals
Alnylam Pharmaceuticals
Omeros Corporation
Segment by Type
Soliris
Ultomiris
Segment by Application
PNH
aHUS
By Region
North America
United States
Canada
Asia-Pacific
China
Japan
South Korea
Southeast Asia
India
Australia
Rest of Asia-Pacific
Europe
Germany
France
U.K.
Italy
Netherlands
Nordic Countries
Rest of Europe
Latin America
Mexico
Brazil
Rest of Latin America
Middle East & Africa
Turkey
Saudi Arabia
UAE
Rest of MEA
Chapter Outline
Chapter 1: Introduces the report scope of the report, global total market size. This chapter also provides the market dynamics, latest developments of the market, the driving factors and restrictive factors of the market, the challenges and risks faced by manufacturers in the industry, and the analysis of relevant policies in the industry.
Chapter 2: Detailed analysis of PNH and aHUS company competitive landscape, revenue market share, latest development plan, merger, and acquisition information, etc.
Chapter 3: Provides the analysis of various market segments by Type, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different market segments.
Chapter 4: Provides the analysis of various market segments by Application, covering the market size and development potential of each market segment, to help readers find the blue ocean market in different downstream markets.
Chapter 5: Revenue of PNH and aHUS in regional level. It provides a quantitative analysis of the market size and development potential of each region and introduces the market development, future development prospects, market space, and market size of each country in the world.
Chapter 6: Revenue of PNH and aHUS in country level. It provides sigmate data by Type, and by Application for each country/region.
Chapter 7: Provides profiles of key players, introducing the basic situation of the main companies in the market in detail, including product revenue, gross margin, product introduction, recent development, etc.
Chapter 8: Analysis of industrial chain, including the upstream and downstream of the industry.
Chapter 9: Conclusion.
Research Methodology
The research methodology employed has been subjected by numerous procedures in order to guarantee the quality and accuracy of the data contained within the reports. The analysts are employed full-time and received more than six months training to satisfy the standard of our company. Our methodology can be divided into five stages:
★Stage 1 SECONDARY RESEARCH
The research team first collaborates with magazines, trade associations and administrative departments in the research field. The information provided by our internal documentation service is helpful for our further research. Our team has a wealth of experience and knowledge, and can effectively extract accurate information from existing resources.
★Stage 2 PRIMARY RESEARCH:INTERVIEWS WITH TRADE SOURCES
After the first stage, the research team conducts a large number of face-to-face or telephone interviews with representative companies working in the research field. Analysts are trying to have an opportunity to talk to leading companies and small companies in the field. Upstream suppliers, manufacturers, distributors, importers, installers, wholesalers and consumers were included in the interview. The data collected during the interview were then carefully examined and compared with the secondary study.
★Stage 3 ANALYSIS OF THE GATHERED DATA
The analysis team examines and synthesizes the data collected in the first two stages. In order to validate the data, a second round of interviews can be conducted.
★Stage 4 QUANTITATIVE DATA
The quantitative data such as market estimates, production and capacity of manufacturer, market forecasts and investment feasibility is provided by our company. The data is based on the estimates obtained during stage 3.
★Stage 5 QUALITY CONTROL
Before publishing, each report undergoes a rigorous review and editing process, which is done by the experience management team to ensure the reliability of the published data. Every analyst on the research team receives support and continuous training as part of our internal quality process.
1 Market Overview
1.1 PNH and aHUS Product Introduction
1.2 Global PNH and aHUS Market Size Forecast (2020-2031)
1.3 PNH and aHUS Market Trends & Drivers
1.3.1 PNH and aHUS Industry Trends
1.3.2 PNH and aHUS Market Drivers & Opportunity
1.3.3 PNH and aHUS Market Challenges
1.3.4 PNH and aHUS Market Restraints
1.4 Assumptions and Limitations
1.5 Study Objectives
1.6 Years Considered
2 Competitive Analysis by Company
2.1 Global PNH and aHUS Players Revenue Ranking (2024)
2.2 Global PNH and aHUS Revenue by Company (2020-2025)
2.3 Key Companies PNH and aHUS Manufacturing Base Distribution and Headquarters
2.4 Key Companies PNH and aHUS Product Offered
2.5 Key Companies Time to Begin Mass Production of PNH and aHUS
2.6 PNH and aHUS Market Competitive Analysis
2.6.1 PNH and aHUS Market Concentration Rate (2020-2025)
2.6.2 Global 5 and 10 Largest Companies by PNH and aHUS Revenue in 2024
2.6.3 Global Top Companies by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in PNH and aHUS as of 2024)
2.7 Mergers & Acquisitions, Expansion
3 Segmentation by Type
3.1 Introduction by Type
3.1.1 Soliris
3.1.2 Ultomiris
3.2 Global PNH and aHUS Sales Value by Type
3.2.1 Global PNH and aHUS Sales Value by Type (2020 VS 2024 VS 2031)
3.2.2 Global PNH and aHUS Sales Value, by Type (2020-2031)
3.2.3 Global PNH and aHUS Sales Value, by Type (%) (2020-2031)
4 Segmentation by Application
4.1 Introduction by Application
4.1.1 PNH
4.1.2 aHUS
4.2 Global PNH and aHUS Sales Value by Application
4.2.1 Global PNH and aHUS Sales Value by Application (2020 VS 2024 VS 2031)
4.2.2 Global PNH and aHUS Sales Value, by Application (2020-2031)
4.2.3 Global PNH and aHUS Sales Value, by Application (%) (2020-2031)
5 Segmentation by Region
5.1 Global PNH and aHUS Sales Value by Region
5.1.1 Global PNH and aHUS Sales Value by Region: 2020 VS 2024 VS 2031
5.1.2 Global PNH and aHUS Sales Value by Region (2020-2025)
5.1.3 Global PNH and aHUS Sales Value by Region (2026-2031)
5.1.4 Global PNH and aHUS Sales Value by Region (%), (2020-2031)
5.2 North America
5.2.1 North America PNH and aHUS Sales Value, 2020-2031
5.2.2 North America PNH and aHUS Sales Value by Country (%), 2024 VS 2031
5.3 Europe
5.3.1 Europe PNH and aHUS Sales Value, 2020-2031
5.3.2 Europe PNH and aHUS Sales Value by Country (%), 2024 VS 2031
5.4 Asia Pacific
5.4.1 Asia Pacific PNH and aHUS Sales Value, 2020-2031
5.4.2 Asia Pacific PNH and aHUS Sales Value by Region (%), 2024 VS 2031
5.5 South America
5.5.1 South America PNH and aHUS Sales Value, 2020-2031
5.5.2 South America PNH and aHUS Sales Value by Country (%), 2024 VS 2031
5.6 Middle East & Africa
5.6.1 Middle East & Africa PNH and aHUS Sales Value, 2020-2031
5.6.2 Middle East & Africa PNH and aHUS Sales Value by Country (%), 2024 VS 2031
6 Segmentation by Key Countries/Regions
6.1 Key Countries/Regions PNH and aHUS Sales Value Growth Trends, 2020 VS 2024 VS 2031
6.2 Key Countries/Regions PNH and aHUS Sales Value, 2020-2031
6.3 United States
6.3.1 United States PNH and aHUS Sales Value, 2020-2031
6.3.2 United States PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.3.3 United States PNH and aHUS Sales Value by Application, 2024 VS 2031
6.4 Europe
6.4.1 Europe PNH and aHUS Sales Value, 2020-2031
6.4.2 Europe PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.4.3 Europe PNH and aHUS Sales Value by Application, 2024 VS 2031
6.5 China
6.5.1 China PNH and aHUS Sales Value, 2020-2031
6.5.2 China PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.5.3 China PNH and aHUS Sales Value by Application, 2024 VS 2031
6.6 Japan
6.6.1 Japan PNH and aHUS Sales Value, 2020-2031
6.6.2 Japan PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.6.3 Japan PNH and aHUS Sales Value by Application, 2024 VS 2031
6.7 South Korea
6.7.1 South Korea PNH and aHUS Sales Value, 2020-2031
6.7.2 South Korea PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.7.3 South Korea PNH and aHUS Sales Value by Application, 2024 VS 2031
6.8 Southeast Asia
6.8.1 Southeast Asia PNH and aHUS Sales Value, 2020-2031
6.8.2 Southeast Asia PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.8.3 Southeast Asia PNH and aHUS Sales Value by Application, 2024 VS 2031
6.9 India
6.9.1 India PNH and aHUS Sales Value, 2020-2031
6.9.2 India PNH and aHUS Sales Value by Type (%), 2024 VS 2031
6.9.3 India PNH and aHUS Sales Value by Application, 2024 VS 2031
7 Company Profiles
7.1 Alexion Pharmaceuticals
7.1.1 Alexion Pharmaceuticals Profile
7.1.2 Alexion Pharmaceuticals Main Business
7.1.3 Alexion Pharmaceuticals PNH and aHUS Products, Services and Solutions
7.1.4 Alexion Pharmaceuticals PNH and aHUS Revenue (US$ Million) & (2020-2025)
7.1.5 Alexion Pharmaceuticals Recent Developments
7.2 Alnylam Pharmaceuticals
7.2.1 Alnylam Pharmaceuticals Profile
7.2.2 Alnylam Pharmaceuticals Main Business
7.2.3 Alnylam Pharmaceuticals PNH and aHUS Products, Services and Solutions
7.2.4 Alnylam Pharmaceuticals PNH and aHUS Revenue (US$ Million) & (2020-2025)
7.2.5 Alnylam Pharmaceuticals Recent Developments
7.3 Omeros Corporation
7.3.1 Omeros Corporation Profile
7.3.2 Omeros Corporation Main Business
7.3.3 Omeros Corporation PNH and aHUS Products, Services and Solutions
7.3.4 Omeros Corporation PNH and aHUS Revenue (US$ Million) & (2020-2025)
7.3.5 Omeros Corporation Recent Developments
8 Industry Chain Analysis
8.1 PNH and aHUS Industrial Chain
8.2 PNH and aHUS Upstream Analysis
8.2.1 Key Raw Materials
8.2.2 Raw Materials Key Suppliers
8.2.3 Manufacturing Cost Structure
8.3 Midstream Analysis
8.4 Downstream Analysis (Customers Analysis)
8.5 Sales Model and Sales Channels
8.5.1 PNH and aHUS Sales Model
8.5.2 Sales Channel
8.5.3 PNH and aHUS Distributors
9 Research Findings and Conclusion
10 Appendix
10.1 Research Methodology
10.1.1 Methodology/Research Approach
10.1.1.1 Research Programs/Design
10.1.1.2 Market Size Estimation
10.1.1.3 Market Breakdown and Data Triangulation
10.1.2 Data Source
10.1.2.1 Secondary Sources
10.1.2.2 Primary Sources
10.2 Author Details
10.3 Disclaimer
List of Tables
Table 1. PNH and aHUS Market Trends
Table 2. PNH and aHUS Market Drivers & Opportunity
Table 3. PNH and aHUS Market Challenges
Table 4. PNH and aHUS Market Restraints
Table 5. Global PNH and aHUS Revenue by Company (2020-2025) & (US$ Million)
Table 6. Global PNH and aHUS Revenue Market Share by Company (2020-2025)
Table 7. Key Companies PNH and aHUS Manufacturing Base Distribution and Headquarters
Table 8. Key Companies PNH and aHUS Product Type
Table 9. Key Companies Time to Begin Mass Production of PNH and aHUS
Table 10. Global PNH and aHUS Companies Market Concentration Ratio (CR5 and HHI)
Table 11. Global Top Companies Market Share by Company Type (Tier 1, Tier 2, and Tier 3) & (based on the Revenue in PNH and aHUS as of 2024)
Table 12. Mergers & Acquisitions, Expansion Plans
Table 13. Global PNH and aHUS Sales Value by Type: 2020 VS 2024 VS 2031 (US$ Million)
Table 14. Global PNH and aHUS Sales Value by Type (2020-2025) & (US$ Million)
Table 15. Global PNH and aHUS Sales Value by Type (2026-2031) & (US$ Million)
Table 16. Global PNH and aHUS Sales Market Share in Value by Type (2020-2025)
Table 17. Global PNH and aHUS Sales Market Share in Value by Type (2026-2031)
Table 18. Global PNH and aHUS Sales Value by Application: 2020 VS 2024 VS 2031 (US$ Million)
Table 19. Global PNH and aHUS Sales Value by Application (2020-2025) & (US$ Million)
Table 20. Global PNH and aHUS Sales Value by Application (2026-2031) & (US$ Million)
Table 21. Global PNH and aHUS Sales Market Share in Value by Application (2020-2025)
Table 22. Global PNH and aHUS Sales Market Share in Value by Application (2026-2031)
Table 23. Global PNH and aHUS Sales Value by Region, (2020 VS 2024 VS 2031) & (US$ Million)
Table 24. Global PNH and aHUS Sales Value by Region (2020-2025) & (US$ Million)
Table 25. Global PNH and aHUS Sales Value by Region (2026-2031) & (US$ Million)
Table 26. Global PNH and aHUS Sales Value by Region (2020-2025) & (%)
Table 27. Global PNH and aHUS Sales Value by Region (2026-2031) & (%)
Table 28. Key Countries/Regions PNH and aHUS Sales Value Growth Trends, (US$ Million): 2020 VS 2024 VS 2031
Table 29. Key Countries/Regions PNH and aHUS Sales Value, (2020-2025) & (US$ Million)
Table 30. Key Countries/Regions PNH and aHUS Sales Value, (2026-2031) & (US$ Million)
Table 31. Alexion Pharmaceuticals Basic Information List
Table 32. Alexion Pharmaceuticals Description and Business Overview
Table 33. Alexion Pharmaceuticals PNH and aHUS Products, Services and Solutions
Table 34. Revenue (US$ Million) in PNH and aHUS Business of Alexion Pharmaceuticals (2020-2025)
Table 35. Alexion Pharmaceuticals Recent Developments
Table 36. Alnylam Pharmaceuticals Basic Information List
Table 37. Alnylam Pharmaceuticals Description and Business Overview
Table 38. Alnylam Pharmaceuticals PNH and aHUS Products, Services and Solutions
Table 39. Revenue (US$ Million) in PNH and aHUS Business of Alnylam Pharmaceuticals (2020-2025)
Table 40. Alnylam Pharmaceuticals Recent Developments
Table 41. Omeros Corporation Basic Information List
Table 42. Omeros Corporation Description and Business Overview
Table 43. Omeros Corporation PNH and aHUS Products, Services and Solutions
Table 44. Revenue (US$ Million) in PNH and aHUS Business of Omeros Corporation (2020-2025)
Table 45. Omeros Corporation Recent Developments
Table 46. Key Raw Materials Lists
Table 47. Raw Materials Key Suppliers Lists
Table 48. PNH and aHUS Downstream Customers
Table 49. PNH and aHUS Distributors List
Table 50. Research Programs/Design for This Report
Table 51. Key Data Information from Secondary Sources
Table 52. Key Data Information from Primary Sources
Table 53. Business Unit and Senior & Team Lead Analysts
List of Figures
Figure 1. PNH and aHUS Product Picture
Figure 2. Global PNH and aHUS Sales Value, 2020 VS 2024 VS 2031 (US$ Million)
Figure 3. Global PNH and aHUS Sales Value (2020-2031) & (US$ Million)
Figure 4. PNH and aHUS Report Years Considered
Figure 5. Global PNH and aHUS Players Revenue Ranking (2024) & (US$ Million)
Figure 6. The 5 and 10 Largest Companies in the World: Market Share by PNH and aHUS Revenue in 2024
Figure 7. PNH and aHUS Market Share by Company Type (Tier 1, Tier 2, and Tier 3): 2020 VS 2024
Figure 8. Soliris Picture
Figure 9. Ultomiris Picture
Figure 10. Global PNH and aHUS Sales Value by Type (2020 VS 2024 VS 2031) & (US$ Million)
Figure 11. Global PNH and aHUS Sales Value Market Share by Type, 2024 & 2031
Figure 12. Product Picture of PNH
Figure 13. Product Picture of aHUS
Figure 14. Global PNH and aHUS Sales Value by Application (2020 VS 2024 VS 2031) & (US$ Million)
Figure 15. Global PNH and aHUS Sales Value Market Share by Application, 2024 & 2031
Figure 16. North America PNH and aHUS Sales Value (2020-2031) & (US$ Million)
Figure 17. North America PNH and aHUS Sales Value by Country (%), 2024 VS 2031
Figure 18. Europe PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 19. Europe PNH and aHUS Sales Value by Country (%), 2024 VS 2031
Figure 20. Asia Pacific PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 21. Asia Pacific PNH and aHUS Sales Value by Region (%), 2024 VS 2031
Figure 22. South America PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 23. South America PNH and aHUS Sales Value by Country (%), 2024 VS 2031
Figure 24. Middle East & Africa PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 25. Middle East & Africa PNH and aHUS Sales Value by Country (%), 2024 VS 2031
Figure 26. Key Countries/Regions PNH and aHUS Sales Value (%), (2020-2031)
Figure 27. United States PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 28. United States PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 29. United States PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 30. Europe PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 31. Europe PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 32. Europe PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 33. China PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 34. China PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 35. China PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 36. Japan PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 37. Japan PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 38. Japan PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 39. South Korea PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 40. South Korea PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 41. South Korea PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 42. Southeast Asia PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 43. Southeast Asia PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 44. Southeast Asia PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 45. India PNH and aHUS Sales Value, (2020-2031) & (US$ Million)
Figure 46. India PNH and aHUS Sales Value by Type (%), 2024 VS 2031
Figure 47. India PNH and aHUS Sales Value by Application (%), 2024 VS 2031
Figure 48. PNH and aHUS Industrial Chain
Figure 49. PNH and aHUS Manufacturing Cost Structure
Figure 50. Channels of Distribution (Direct Sales, and Distribution)
Figure 51. Bottom-up and Top-down Approaches for This Report
Figure 52. Data Triangulation
Figure 53. Key Executives Interviewed
